DBT-JRF brief notes [Bioinformatics] PART -1

Facts and information about Bioinformatics especially for DBT-JRF: [Part -1]

These notes are only for the students who are not interested in Bioinformatics but want to solve and memorize the common questions in DBT-JRF.

DOT BLOT: Pairwise sequence similarity

Protein database:

Try to recall the names and the subcategories.

E- value:

BLAST:

Have a look at the difference between local and global alignment.

If a nucleotide sequence encoding a protein is known and a homologous protein to be identified, --> the best analysis tool is BLASTx.

Read the following:

Substitution Matrix: [Along with PAM and BLOSUM]

These notes are based on the PYQs.

Similarity search:

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Why oxytocin and vasopressin called as 'neuro hormone'?

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A brief description of Keto diet

Keto diet: How does this diet work: The establishment of the keto diet is if glucose (the simplest form of carbohydrate as well as the main source of energy in every animal) is deprived, which is gained by consuming carbs. The ketones are a substitution of glucose, which is synthesized from stored fat. Hence, the name is ketogenic. The neurocytes (The brain cells) need glucose approximately 120 grams per day because these cells cannot store glucose. When a person is fasting or consumes very little carbohydrates, at first the body pulls glucose from the liver and muscle glycogen. Glycogen breaks down from the liver and muscle into glucose through glycogenolysis by the influence of the hormone glucagon. During this time the level of insulin gets decreased in the blood. The body starts utilizing fat as its primary fuel. When formed ketone bodies begin to accumulate in the organs as well as in the blood, the condition is called ketosis. Mild ketosis is usually experienced by e...

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