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Plasmapheresis

 Plasmapheresis

- Souti Das



 In this experiment, the dog is rendered hypoproteinaemic by repeatedly withdrawing whole blood and injecting back the cellular elements of the blood (suspended in Ringer-Locke solution). This process is repeated daily till the level of plasma proteins fails to 4g/100 ml. Thereafter different standard diets are given and their effects on protein synthesis are studied. Following conclusions have been drawn from this experiment:

Dietary proteins are essential for synthesis of plasma proteins.

Chemical resemblance of food protein amino acid with those of the plasma proteins to be synthesized determines their efficacy to synthesize a particular protein.

Essential amino acid must be present in the diet for the satisfactory synthesis of plasma proteins.

Dietary proteins of animal origin favours albumin synthesis.

Dietary proteins of plant origin favours globulin synthesis.

Regeneration of plasma proteins occurs within 14 days.

Rate of regeneration of plasma protein is very fast within first 24 hours.

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