Plasmapheresis
- Souti Das
In this experiment, the dog is rendered hypoproteinaemic by repeatedly withdrawing whole blood and injecting back the cellular elements of the blood (suspended in Ringer-Locke solution). This process is repeated daily till the level of plasma proteins fails to 4g/100 ml. Thereafter different standard diets are given and their effects on protein synthesis are studied. Following conclusions have been drawn from this experiment:
• Dietary proteins are essential for synthesis of plasma proteins.
• Chemical resemblance of food protein amino acid with those of the plasma proteins to be synthesized determines their efficacy to synthesize a particular protein.
• Essential amino acid must be present in the diet for the satisfactory synthesis of plasma proteins.
• Dietary proteins of animal origin favours albumin synthesis.
• Dietary proteins of plant origin favours globulin synthesis.
• Regeneration of plasma proteins occurs within 14 days.
• Rate of regeneration of plasma protein is very fast within first 24 hours.
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