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Top 6 Online Database used in Bioinformatics

RESOURCESS USE IN BIOINFORMATICS

👉Sequence database:

1. Uniprot: UniProt is the Universal Protein resource, a central repository of protein data created by combining the Swiss-Prot, TrEMBL and PIR-PSD databases.

Web adress:  https://www.uniprot.org/

               

2. NCBI: The National Center for Biotechnology Information (NCBI) is part of the United States National Library of Medicine (NLM), a branch of the National Institutes of Health (NIH).

                   

                    Website -   http://www.ncbi.nlm.nih.gov/

  The NCBI houses a series of databases relevant to biotechnology and biomedicine and is an important resource for bioinformatics tools and services. Major databases include GenBank for DNA sequences and PubMed, a bibliographic database for the biomedical literature. Other databases include the NCBI Epigenomics database. All these databases are available online through the Entrez search engine. NCBI was directed by David Lipman, one of the original authors of the BLAST sequence alignment program and a widely respected figure in bioinformatics.

3. Ensembl: Ensembl genome database project is a joint scientific project between the European Bioinformatics Institute and the Wellcome Trust Sanger Institute, which was launched in 1999 in response to the imminent completion of the Human Genome Project. Ensembl aims to provide a centralized resource for geneticists, molecular biologists and other researchers studying the genomes of our own species and other vertebrates and model organisms.Ensembl is one of several well known genome browsers for the retrieval of genomic information.

Website: www.ensembl.org


                    

👉 Structure database:

1. PDB: The Protein Data Bank (PDB) is a database for the three-dimensional structural data of large biological molecules, such as proteins and nucleic acids. The data, typically obtained by X-ray crystallography, NMR spectroscopy, or, increasingly, cryo-electron microscopy, and submitted by biologists and biochemists from around the world, are freely accessible on the Internet via the websites of its member organisations.

Website: www.rcsb.org

                    

2. NDB: The NDB contains information about experimentally-determined nucleic acids and complex assemblies.Use the NDB to perform searches based on annotations relating to sequence, structure and function, and to download, analyze, and learn about nucleic acids.

Website: ndbserver.rutgers.edu

                     


3. Pfam: Pfam is a database of protein families that includes their annotations and multiple sequence alignments generated using hidden Markov models. The most recent version, Pfam 32.0, was released in September 2018 and contains 17,929 families. The general purpose of the Pfam database is to provide a complete and accurate classification of protein families and domains.

Website: pfam.xfam.org

       

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