Skip to main content

TDP Of Insulin

 Time Dependent Potentiation of Insulin secretion 
Glucose causes time dependent potentiation(TDP) of insulin secretion; that is exposure of islets beta cells to high glucose enhances insulin release in response to the stimulus applied later. Metabolizable amino acids and the glycolytic intermediates, glyceraldehyde show similar enhancement of insulin secretion. Conversely, non-metabolizable secretagogues, such as sulfanylurea(SU) and high K+, do not prime the beta cells in this TDP manner. In contrast merabolic inhibition abolishes TDP by glucose and the amino acids. Therefore metabolic stimulus, the mitochondrial intermediates in the case of amino acids, is required for TDP. Pharmacological activation of protein kinase C (pkC) by phorbolester also timedependently potentiates insulin secretion.             
    The beta cell priming by glucose through TDP manner occurs in a KATP channel independent manner. TDP also occurs under stringent Ca2+ free conditions.
by -Souti Das
Labels:

Comments

Post a Comment

please share it with your friends and students

Popular posts from this blog

TOP 5 BOOKS ON HUMAN PHYSIOLOGY

Post a Comment
Read more

INTRODUCTION TO RECOMBINANT DNA TECHNOLOGY(RDT) WITH ITS STEP AND APPLICATION

  INTRODUCTION TO RECOMBINANT DNA TECHNOLOGY(RDT) - Devlina Sarkar v What is Recombinant DNA technology ? RDT is a series of procedures that is used to join together (recombine) DNA segments from different organisms and inserting it into a host organism to produce new genetic combinations. v What is called Recombinant DNA ? Recombinant DNA (rDNA) is   m olecules  of  DNA  from two different species that are inserted into a host organism to produce new genetic combinations that are of value to science, medicine, agriculture, and industry. Recombinant DNA in a living organism was first achieved in 1973 by  Herbert Boyer , of the University of California at San Francisco, and  Stanley Cohen , at Stanford University , who used   E. coli  restriction enzymes to insert foreign DNA into plasmids. v What is the basic use of RDT? Using RDT we can get a huge no of copies/clones of a particular gene or DNA(cloning) by usi...
Post a Comment
Read more

COVID 19 - A brief details about COVID-19 , HISTORY, STRUCTURE, MODE OF TRANSMISSION, MODE OF ACTION and SYMPTOMS

 COVID-19 - Eishika Das,  -Soumyaprabha Ganguly HISTORY:  Coronavirus disease 2019  ( COVID-19 ) is an  infectious disease  caused by  severe acute respiratory syndrome coronavirus 2  (SARS-CoV-2) The disease was first identified in 2019 in  Wuhan , the capital of  Hubei , China, and has since spread globally, resulting in the  2019–20 coronavirus pandemic . According to the World Health Organization (WHO), viral diseases continue to emerge and represent a serious issue to public health. In the last twenty years, several viral epidemics such as the severe acute respiratory syndrome coronavirus (SARS-CoV) in 2002 to 2003 beginning in China and involving two dozen countries with approximately 8000 cases and 800 deaths , and H1N1 influenza in 2009, have been recorded. Most recently, the Middle East respiratory syndrome coronavirus (MERS-CoV) was first identified in Saudi Arabia in 2012 approximately 2,500 cases and 800...
Post a Comment
Read more